Top
Summary
All studies
Mortality
Ventilation
ICU
Hospitalization
Serious outcomes
Recovery
Viral clearance
RCTs
RCT mortality
Peer-reviewed
All outcomes

Feedback
Analgesics⏵
Antiandrogens⏵
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle⏵
Melatonin
Metformin
Minerals⏵
Molnupiravir
Monoclonals⏵
Naso/orophar..⏵
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins⏵
More⏵

Other
Feedback
Home
Top
All convalescent plasma..
 
Feedback
Home
c19early.org COVID-19 treatment researchConvalescent PlasmaConv. Plasma (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta
Home Adoption Other Treatments
@CovidAnalysis

Outcomes in COVID-19 convalescent plasma studies

Home
Post
Share
@CovidAnalysis
StudiesStudies
FeedbackFeedback
All studies   Mortality   Ventilation   ICU   Hospitalization   Serious outcomes   Recovery   Viral clearance   RCTs   RCT mortality   Peer-reviewed   All outcomes  
0 0.5 1 1.5+ All studies -1% 53 30,630 Improvement, Studies, Patients Relative Risk Mortality -1% 51 29,488 Ventilation 1% 16 3,083 ICU admission -9% 9 2,776 Hospitalization -2% 16 3,936 Progression 2% 12 2,659 Recovery -0% 9 14,198 Viral clearance 4% 8 1,541 RCTs -0% 46 24,540 RCT mortality -0% 44 23,398 Peer-reviewed -1% 47 30,072 Early -58% 6 1,580 Late -1% 47 29,050 Convalescent Plasma for COVID-19 c19early.org October 2024 Favorsconv. plasma Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 RES-Q-HR Keitel-A.. (DB RCT) unknown, >2 years late 22 (total) Tau​2​ = 0.36, I​2​ = 22.8%, p = 0.38 Early treatment -58% 1.58 [0.57-4.36] 16/802 10/778 58% higher risk Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Gonzalez -7% 1.07 [0.76-1.50] death 60/130 26/60 OT​1​ Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] death 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Cho -4% 1.04 [0.64-1.62] death 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 Mesina -29% 1.29 [0.70-2.36] death 18/65 14/65 De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] death 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 Alshamrani (PSM) -14% 1.14 [0.79-1.45] death 24/41 108/205 Krishnan -270% 3.70 [0.90-15.8] death case control Kasten -4% 1.04 [0.49-2.21] death 7/19 11/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 Lewandowski -62% 1.62 [0.88-2.98] death 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 Sevdi (DB RCT) unknown, >4 years late 60 (total) Averyanov (RCT) unknown, >4 years late 60 (total) PC-COVID-HCM Torres (DB RCT) unknown, >4 years late 150 (total) Chowdhury (RCT) unknown, >3 years late 60 (est. total) Lubis (RCT) unknown, >3 years late 60 (est. total) Cardesa Gil (RCT) unknown, >3 years late 72 (total) Zuluaga (SB RCT) unknown, >3 years late 60 (est. total) EPCOvid-1 Sierra-M.. (DB RCT) unknown, >3 years late 410 (est. total) PLASMA COVID-19 Quintero.. (SB RCT) unknown, >3 years late 236 (est. total) MBT Torres (RCT) unknown, >3 years late 200 (total) CoV-PlasGal Fundacin B.. (RCT) unknown, >3 years late 61 (total) COP-COVID-19 Camacho.. (DB RCT) unknown, >3 years late 31 (total) Herrick (DB RCT) unknown, >3 years late 50 (est. total) COV2-CP Talarico (RCT) unknown, >3 years late 400 (est. total) PLASCOSSA Martinaud (DB RCT) unknown, >3 years late 18 (total) Gonzalez (RCT) unknown, >3 years late 134 (total) ESCAPE Kaufman (DB RCT) unknown, >3 years late 45 (total) FUTILITY, PENDING​2​ Pathak (RCT) unknown, >3 years late 100 (total) IPCO Schiffer (RCT) unknown, >3 years late 58 (est. total) Perilla (RCT) unknown, >2 years late 231 (est. total) de la Pu.. (DB RCT) unknown, >2 years late 93 (total) PlaSenTer Karyana (RCT) unknown, >2 years late 364 (est. total) CP IN COVID19 ElDesouky (RCT) unknown, >2 years late 67 (est. total) Dillner (RCT) unknown, >2 years late 59 (total) Rego (RCT) unknown, >2 years late 60 (est. total) Itinose (RCT) unknown, >2 years late 38 (total) COVID-PLEX Perner (RCT) unknown, >2 years late 220 (est. total) Baylor Rese.. (RCT) unknown, >1.5 years late 115 (est. total) Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.61 Late treatment -1% 1.01 [0.97-1.05] 2,881/12,583 2,792/16,037 1% higher risk All studies -1% 1.01 [0.97-1.05] 2,897/13,385 2,802/16,815 1% higher risk 53 convalescent plasma COVID-19 studies (+29 unreported RCTs) c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.57 Effect extraction pre-specified ​1​ OT: comparison with other treatment​2​ FUTILITY: terminated for futility, results pending Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] 5/28 2/30 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] 1/207 1/209 Tau​2​ = 0.49, I​2​ = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 36% higher risk Li (RCT) 35% 0.65 [0.27-1.39] 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] 1,399/5,795 1,408/5,763 Gonzalez -7% 1.07 [0.76-1.50] 60/130 26/60 OT​1​ Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] 6/43 11/43 Cho -4% 1.04 [0.64-1.62] 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] 11/52 13/51 Mesina -29% 1.29 [0.70-2.36] 18/65 14/65 De Santis (RCT) 13% 0.87 [0.48-1.56] 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] 68 (n) 66 (n) Alshamrani (PSM) -14% 1.14 [0.79-1.45] 24/41 108/205 Krishnan -270% 3.70 [0.90-15.8] case control Kasten -4% 1.04 [0.49-2.21] 7/19 11/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] 2/22 0/22 Lewandowski -62% 1.62 [0.88-2.98] 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] 1/37 0/20 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.65 Late treatment -1% 1.01 [0.96-1.06] 2,500/12,045 2,411/15,505 1% higher risk All studies -1% 1.01 [0.97-1.06] 2,513/12,798 2,421/16,260 1% higher risk 51 convalescent plasma COVID-19 mortality results c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.63 ​1​ OT: comparison with other treatment Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -163% 2.63 [0.43-9.10] 5/28 2/30 CoV-Early Gharbharan (DB RCT) 67% 0.33 [0.01-8.16] 0/207 1/209 Tau​2​ = 0.30, I​2​ = 22.8%, p = 1. Early treatment 0% 1.00 [0.28-3.54] 7/315 7/319 0% lower risk PLACID Agarwal (RCT) 1% 0.99 [0.54-1.81] 19/227 19/224 Improvement, RR [CI] Treatment Control ILBS-COVID-02 Bajpai (RCT) -221% 3.21 [0.38-27.4] 3/14 1/15 AlQahtani (RCT) 33% 0.67 [0.22-2.01] 4/20 6/20 CAPRI Hsue (DB RCT) -425% 5.25 [0.27-102] 2/16 0/18 DAWn-plasma Devos (RCT) -8% 1.08 [0.65-1.80] 320 (n) 163 (n) TSUNAMI Menichetti (RCT) -4% 1.04 [0.62-1.75] 25/231 25/240 COP20 Holm (RCT) 69% 0.31 [0.01-7.09] 0/17 1/14 PennCCP2 Bar (RCT) 51% 0.49 [0.18-1.30] 5/40 10/39 PROTECT-Patient van den Berg (RCT) 67% 0.33 [0.04-3.04] 1/52 3/51 COPLA-II Bajpai (RCT) -12% 1.12 [0.67-1.88] 27/200 24/200 CCAP-2 Thorlaci.. (DB RCT) -37% 1.37 [0.29-6.52] 6/94 2/43 Denkinger (RCT) -2% 1.02 [0.59-1.77] 19/68 18/66 CP_COVID-19 Khawaja (DB RCT) 73% 0.27 [0.03-2.80] 1/37 2/20 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.95 Late treatment 1% 0.99 [0.80-1.24] 112/1,336 111/1,113 1% lower risk All studies 1% 0.99 [0.80-1.24] 119/1,651 118/1,432 1% lower risk 16 convalescent plasma COVID-19 mechanical ventilation results c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.96 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 67% 0.33 [0.07-1.60] 2/80 6/80 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.17 Early treatment 67% 0.33 [0.07-1.60] 2/80 6/80 67% lower risk DAWn-plasma Devos (RCT) 0% 1.00 [0.74-1.34] 320 (n) 163 (n) Improvement, RR [CI] Treatment Control Sullivan (DB RCT) 25% 0.75 [0.17-3.32] 3/592 4/589 Jalili (RCT) -8% 1.08 [0.72-1.63] 27/60 25/60 COPLA-II Bajpai (RCT) -2% 1.02 [0.90-1.15] 200 (n) 200 (n) CCAP-2 Thorlaci.. (DB RCT) -31% 1.31 [0.45-3.82] 12/89 4/39 Alshamrani (PSM) -43% 1.43 [1.13-1.80] 37 (n) 166 (n) Co-CLARITY Gauiran (RCT) -100% 2.00 [0.20-20.5] 2/22 1/22 CP_COVID-19 Khawaja (DB RCT) 46% 0.54 [0.12-2.43] 3/37 3/20 Tau​2​ = 0.00, I​2​ = 12.7%, p = 0.15 Late treatment -10% 1.10 [0.97-1.25] 47/1,357 37/1,259 10% higher risk All studies -9% 1.09 [0.94-1.27] 49/1,437 43/1,339 9% higher risk 9 convalescent plasma COVID-19 ICU results c19early.org October 2024 Tau​2​ = 0.01, I​2​ = 21.6%, p = 0.24 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 Improvement, RR [CI] Treatment Control C3PO Korley (RCT) 10% 0.90 [0.64-1.26] hosp. 51/257 56/254 Alemany (DB RCT) -5% 1.05 [0.60-1.84] hosp. 22/188 21/188 CoV-Early Gharbharan (DB RCT) 39% 0.61 [0.28-1.34] hosp. 10/207 18/209 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.45 Early treatment 10% 0.90 [0.69-1.18] 86/701 95/674 10% lower risk ILBS-COVID-02 Bajpai (RCT) 25% 0.75 [0.54-1.04] hosp. time 14 (n) 15 (n) Improvement, RR [CI] Treatment Control AlQahtani (RCT) 22% 0.78 [0.57-1.07] hosp. time 20 (n) 20 (n) Pouladza.. (SB RCT) -30% 1.30 [0.99-1.71] hosp. time 30 (n) 30 (n) PLACOVID Sekine (RCT) -67% 1.67 [0.01-470] hosp. time 80 (n) 80 (n) COP20 Holm (RCT) -62% 1.62 [0.76-3.46] hosp. time 17 (n) 14 (n) Sullivan (DB RCT) 54% 0.46 [0.26-0.80] hosp. 17/592 37/589 Jalili (RCT) -10% 1.10 [0.89-1.36] hosp. time 60 (n) 60 (n) Mesina -60% 1.60 [0.96-2.65] hosp. time 65 (n) 65 (n) COPLA-II Bajpai (RCT) 0% 1.00 [0.91-1.09] hosp. time 200 (n) 200 (n) CORIPLASM Lacombe (RCT) -7% 1.07 [0.00-9700] hosp. time 60 (n) 60 (n) Alshamrani (PSM) -32% 1.32 [1.07-1.63] hosp. time 41 (n) 205 (n) Co-CLARITY Gauiran (RCT) -7% 1.07 [0.77-1.50] hosp. time 22 (n) 22 (n) Tau​2​ = 0.03, I​2​ = 60.7%, p = 0.64 Late treatment -4% 1.04 [0.89-1.20] 17/1,201 37/1,360 4% higher risk All studies -2% 1.02 [0.89-1.16] 103/1,902 132/2,034 2% higher risk 16 convalescent plasma COVID-19 hospitalization results c19early.org October 2024 Tau​2​ = 0.03, I​2​ = 52.7%, p = 0.83 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2​ = 0.36, I​2​ = 22.8%, p = 0.38 Early treatment -58% 1.58 [0.57-4.36] 16/802 10/778 58% higher risk Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Gonzalez -7% 1.07 [0.76-1.50] death 60/130 26/60 OT​1​ Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] death 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Cho -4% 1.04 [0.64-1.62] death 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 Mesina -29% 1.29 [0.70-2.36] death 18/65 14/65 De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] death 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) Alshamrani (PSM) -14% 1.14 [0.79-1.45] death 24/41 108/205 Krishnan -270% 3.70 [0.90-15.8] death case control Kasten -4% 1.04 [0.49-2.21] death 7/19 11/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 Lewandowski -62% 1.62 [0.88-2.98] death 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.65 Late treatment -1% 1.01 [0.96-1.06] 2,500/12,045 2,411/15,505 1% higher risk All studies -1% 1.01 [0.97-1.06] 2,516/12,847 2,421/16,283 1% higher risk 52 convalescent plasma COVID-19 serious outcomes c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.61 Effect extraction pre-specified(most serious outcome) ​1​ OT: comparison with other treatment Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Alemany (DB RCT) -5% 1.05 [0.85-1.30] no recov. 188 (n) 188 (n) Improvement, RR [CI] Treatment Control CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.88-1.16] no recov. 137/207 137/209 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.73 Early treatment -2% 1.02 [0.91-1.15] 137/395 137/397 2% higher risk RECOVERY Recovery Co.. (RCT) -1% 1.01 [0.97-1.06] no disch. 1,963/5,795 1,941/5,763 Improvement, RR [CI] Treatment Control ConCoVid-19 Gharbharan (RCT) 12% 0.88 [0.49-1.60] no disch. 43 (n) 43 (n) CAPSID Körper (RCT) 16% 0.84 [0.62-1.14] no recov. 30/53 35/52 PROTECT-Patient van den Berg (RCT) -3% 1.03 [0.62-1.71] no disch. 18/46 19/50 COPLA-II Bajpai (RCT) 6% 0.94 [0.71-1.24] no recov. 64/200 68/200 Rojas (SB RCT) 38% 0.62 [0.40-0.97] no disch. 46 (n) 45 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 Tau​2​ = 0.00, I​2​ = 2.7%, p = 0.97 Late treatment 0% 1.00 [0.96-1.04] 2,456/6,721 2,444/6,685 0% lower risk All studies -0% 1.00 [0.96-1.04] 2,593/7,116 2,581/7,082 0% higher risk 9 convalescent plasma COVID-19 recovery results c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.9 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Alemany (DB RCT) -4% 1.04 [0.97-1.11] viral load 188 (n) 188 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.33 Early treatment -4% 1.04 [0.97-1.11] 188 (n) 188 (n) 4% higher risk Li (RCT) 76% 0.24 [0.07-0.64] viral+ 4/26 15/23 Improvement, RR [CI] Treatment Control PLACID Agarwal (RCT) 28% 0.72 [0.55-0.95] viral+ 56/173 76/169 ILBS-COVID-02 Bajpai (RCT) 33% 0.67 [0.41-1.10] viral load 14 (n) 15 (n) COVIDIT Kirenga (RCT) -50% 1.50 [0.81-2.77] viral time 67 (n) 67 (n) COPLA-II Bajpai (RCT) -1% 1.01 [0.98-1.05] viral+ 200 (n) 200 (n) Rojas (SB RCT) -25% 1.25 [0.36-4.33] viral+ 46 (n) 45 (n) PLACO COVID Manzini (DB RCT) -6% 1.06 [0.70-1.61] viral time 60 (n) 60 (n) Tau​2​ = 0.06, I​2​ = 68.9%, p = 0.28 Late treatment 13% 0.87 [0.67-1.12] 60/586 91/579 13% lower risk All studies 4% 0.96 [0.85-1.07] 60/774 91/767 4% lower risk 8 convalescent plasma COVID-19 viral clearance results c19early.org October 2024 Tau​2​ = 0.01, I​2​ = 64.9%, p = 0.46 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 RES-Q-HR Keitel-A.. (DB RCT) unknown, >2 years late 22 (total) Tau​2​ = 0.36, I​2​ = 22.8%, p = 0.38 Early treatment -58% 1.58 [0.57-4.36] 16/802 10/778 58% higher risk Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] death 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] death 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 Sevdi (DB RCT) unknown, >4 years late 60 (total) Averyanov (RCT) unknown, >4 years late 60 (total) PC-COVID-HCM Torres (DB RCT) unknown, >4 years late 150 (total) Chowdhury (RCT) unknown, >3 years late 60 (est. total) Lubis (RCT) unknown, >3 years late 60 (est. total) Cardesa Gil (RCT) unknown, >3 years late 72 (total) Zuluaga (SB RCT) unknown, >3 years late 60 (est. total) EPCOvid-1 Sierra-M.. (DB RCT) unknown, >3 years late 410 (est. total) PLASMA COVID-19 Quintero.. (SB RCT) unknown, >3 years late 236 (est. total) MBT Torres (RCT) unknown, >3 years late 200 (total) CoV-PlasGal Fundacin B.. (RCT) unknown, >3 years late 61 (total) COP-COVID-19 Camacho.. (DB RCT) unknown, >3 years late 31 (total) Herrick (DB RCT) unknown, >3 years late 50 (est. total) COV2-CP Talarico (RCT) unknown, >3 years late 400 (est. total) PLASCOSSA Martinaud (DB RCT) unknown, >3 years late 18 (total) Gonzalez (RCT) unknown, >3 years late 134 (total) ESCAPE Kaufman (DB RCT) unknown, >3 years late 45 (total) FUTILITY, PENDING​1​ Pathak (RCT) unknown, >3 years late 100 (total) IPCO Schiffer (RCT) unknown, >3 years late 58 (est. total) Perilla (RCT) unknown, >2 years late 231 (est. total) de la Pu.. (DB RCT) unknown, >2 years late 93 (total) PlaSenTer Karyana (RCT) unknown, >2 years late 364 (est. total) CP IN COVID19 ElDesouky (RCT) unknown, >2 years late 67 (est. total) Dillner (RCT) unknown, >2 years late 59 (total) Rego (RCT) unknown, >2 years late 60 (est. total) Itinose (RCT) unknown, >2 years late 38 (total) COVID-PLEX Perner (RCT) unknown, >2 years late 220 (est. total) Baylor Rese.. (RCT) unknown, >1.5 years late 115 (est. total) Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.9 Late treatment -0% 1.00 [0.96-1.05] 2,772/11,926 2,633/11,034 0% higher risk All studies -0% 1.00 [0.96-1.05] 2,788/12,728 2,643/11,812 0% higher risk 46 convalescent plasma COVID-19 Randomized Controlled Trials c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.86 Effect extraction pre-specified ​1​ FUTILITY: terminated for futility, results pending Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] 5/28 2/30 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] 1/207 1/209 Tau​2​ = 0.49, I​2​ = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 36% higher risk Li (RCT) 35% 0.65 [0.27-1.39] 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] 1,399/5,795 1,408/5,763 Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] 6/43 11/43 PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] 11/52 13/51 De Santis (RCT) 13% 0.87 [0.48-1.56] 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] 68 (n) 66 (n) Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] 2/22 0/22 CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] 1/37 0/20 Tau​2​ = 0.00, I​2​ = 0.0%, p = 1. Late treatment -0% 1.00 [0.95-1.05] 2,391/11,388 2,252/10,502 0% higher risk All studies -0% 1.00 [0.95-1.05] 2,404/12,141 2,262/11,257 0% higher risk 44 convalescent plasma COVID-19 RCT mortality results c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2​ = 0.49, I​2​ = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 36% higher risk Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Cho -4% 1.04 [0.64-1.62] death 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 Alshamrani (PSM) -14% 1.14 [0.79-1.45] death 24/41 108/205 Krishnan -270% 3.70 [0.90-15.8] death case control Kasten -4% 1.04 [0.49-2.21] death 7/19 11/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 Lewandowski -62% 1.62 [0.88-2.98] death 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.66 Late treatment -1% 1.01 [0.97-1.05] 2,794/12,308 2,739/15,826 1% higher risk All studies -1% 1.01 [0.97-1.05] 2,807/13,061 2,749/16,581 1% higher risk 47 convalescent plasma COVID-19 peer reviewed studies c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.64 Effect extraction pre-specified(most serious outcome) Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] ventilation 2/80 4/80 INFANT-COVID-19 Libster (DB RCT) 67% 0.33 [0.07-1.60] ICU 2/80 6/80 INFANT-COVID-19 Libster (DB RCT) 48% 0.52 [0.29-0.94] progression 13/80 25/80 Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Balcells (RCT) -163% 2.63 [0.43-9.10] ventilation 5/28 2/30 Balcells (RCT) -23% 1.23 [0.56-1.89] progression 13/28 12/30 Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 C3PO Korley (RCT) 10% 0.90 [0.64-1.26] hosp. 51/257 56/254 C3PO Korley (RCT) 6% 0.94 [0.72-1.22] progression 77/257 81/254 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 Alemany (DB RCT) -5% 1.05 [0.60-1.84] hosp. 22/188 21/188 Alemany (DB RCT) -5% 1.05 [0.85-1.30] no recov. 188 (n) 188 (n) Alemany (DB RCT) -4% 1.04 [0.97-1.11] viral load 188 (n) 188 (n) Alemany (DB RCT) 4% 0.96 [0.88-1.05] viral load 188 (n) 188 (n) CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 CoV-Early Gharbharan (DB RCT) 67% 0.33 [0.01-8.16] ventilation 0/207 1/209 CoV-Early Gharbharan (DB RCT) 14% 0.86 [0.59-1.22] progression 207 (n) 209 (n) CoV-Early Gharbharan (DB RCT) 42% 0.58 [0.33-1.02] progression 123 (n) 103 (n) CoV-Early Gharbharan (DB RCT) 39% 0.61 [0.28-1.34] hosp. 10/207 18/209 CoV-Early Gharbharan (DB RCT) -50% 1.50 [0.40-5.64] hosp. time 207 (n) 209 (n) CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.88-1.16] no recov. 137/207 137/209 CoV-Early Gharbharan (DB RCT) -8% 1.1 [0.00-9e+04] recov. time 207 (n) 209 (n) Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Li (RCT) 15% 0.85 [0.53-1.18] no improv. 25/52 29/51 Li (RCT) 76% 0.24 [0.07-0.64] viral+ 4/26 15/23 ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 ConPlas-19 Avendaño-Solà (RCT) 93% 0.07 [0.01-0.57] progression 0/38 7/43 ConPlas-19 Avendaño-Solà (RCT) 92% 0.08 [0.01-0.76] progression 0/38 6/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] progression 44/235 41/229 PLACID Agarwal (RCT) 1% 0.99 [0.54-1.81] ventilation 19/227 19/224 PLACID Agarwal (RCT) 28% 0.72 [0.55-0.95] viral+ 56/173 76/169 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 ILBS-COVID-02 Bajpai (RCT) -114% 2.14 [0.22-21.1] death 2/14 1/15 ILBS-COVID-02 Bajpai (RCT) -221% 3.21 [0.38-27.4] ventilation 3/14 1/15 ILBS-COVID-02 Bajpai (RCT) 25% 0.75 [0.54-1.04] hosp. time 14 (n) 15 (n) ILBS-COVID-02 Bajpai (RCT) 33% 0.67 [0.41-1.10] viral load 14 (n) 15 (n) AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 AlQahtani (RCT) 33% 0.67 [0.22-2.01] ventilation 4/20 6/20 AlQahtani (RCT) 22% 0.78 [0.57-1.07] hosp. time 20 (n) 20 (n) PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 PlasmAr Simonovich (RCT) 19% 0.81 [0.50-1.31] 7-point status 228 (n) 105 (n) Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 RECOVERY Recovery Co.. (RCT) -1% 1.01 [0.97-1.06] no disch. 1,963/5,795 1,941/5,763 Gonzalez -7% 1.07 [0.76-1.50] death 60/130 26/60 OT​1​ Gonzalez -1% 1.01 [0.76-1.34] death 70/130 32/60 OT​1​ Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Pouladza.. (SB RCT) -30% 1.30 [0.99-1.71] hosp. time 30 (n) 30 (n) Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 Bennett-.. (DB RCT) 11% 0.89 [0.34-2.31] death 14/59 4/15 Bennett-.. (DB RCT) 0% 1.00 [0.75-1.32] no improv. 47/59 12/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] death 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 ConCoVid-19 Gharbharan (RCT) 12% 0.88 [0.49-1.60] no disch. 43 (n) 43 (n) Cho -4% 1.04 [0.64-1.62] death 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 PLACOVID Sekine (RCT) -100% 2.00 [0.72-5.59] death 10/80 5/80 PLACOVID Sekine (RCT) -11% 1.11 [0.74-1.66] no improv. 31/80 28/80 PLACOVID Sekine (RCT) -67% 1.67 [0.01-470] hosp. time 80 (n) 80 (n) COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 COVIDIT Kirenga (RCT) 9% 0.91 [0.38-2.16] progression 9/41 7/29 COVIDIT Kirenga (RCT) -50% 1.50 [0.81-2.77] viral time 67 (n) 67 (n) CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 CAPRI Hsue (DB RCT) -12% 1.12 [0.08-16.6] death 1/16 1/18 CAPRI Hsue (DB RCT) -425% 5.25 [0.27-102] ventilation 2/16 0/18 CAPRI Hsue (DB RCT) -425% 5.25 [0.27-102] progression 2/16 0/18 CAPRI Hsue (DB RCT) -425% 5.25 [0.27-102] progression 2/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) DAWn-plasma Devos (RCT) -8% 1.08 [0.65-1.80] ventilation 320 (n) 163 (n) DAWn-plasma Devos (RCT) 0% 1.00 [0.74-1.34] ICU 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CONCOR-1 Bégin (RCT) -12% 1.12 [0.86-1.46] death 141/614 63/307 CONCOR-1 Bégin (RCT) -16% 1.16 [0.94-1.43] death/int. 199/614 86/307 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 CAPSID Körper (RCT) 14% 0.86 [0.34-2.20] death 7/53 8/52 CAPSID Körper (RCT) 16% 0.84 [0.62-1.14] no recov. 30/53 35/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 TSUNAMI Menichetti (RCT) -4% 1.04 [0.62-1.75] ventilation 25/231 25/240 TSUNAMI Menichetti (RCT) 12% 0.88 [0.59-1.33] progression 59/231 67/239 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 COP20 Holm (RCT) 69% 0.31 [0.01-7.09] ventilation 0/17 1/14 COP20 Holm (RCT) 19% 0.81 [0.25-2.64] progression 4/16 4/13 COP20 Holm (RCT) -57% 1.57 [0.52-4.74] oxygen time 17 (n) 14 (n) COP20 Holm (RCT) -62% 1.62 [0.76-3.46] hosp. time 17 (n) 14 (n) CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 CONTAIN COVID-19 Ortigoza (DB RCT) 1% 0.99 [0.66-1.47] death 35/463 39/463 CONTAIN COVID-19 Ortigoza (DB RCT) 8% 0.92 [0.74-1.16] WHO scale 468 (n) 473 (n) CONTAIN COVID-19 Ortigoza (DB RCT) 6% 0.94 [0.75-1.18] WHO scale 468 (n) 473 (n) CONTAIN COVID-19 Ortigoza (DB RCT) -2% 1.02 [0.77-1.37] PASC 141 (n) 140 (n) CONTAIN COVID-19 Ortigoza (DB RCT) 5% 0.95 [0.54-1.67] PASC 141 (n) 140 (n) CONTAIN COVID-19 Ortigoza (DB RCT) -15% 1.15 [0.59-2.25] PASC 141 (n) 140 (n) CONTAIN COVID-19 Ortigoza (DB RCT) 18% 0.82 [0.44-1.51] PASC 141 (n) 140 (n) CONTAIN COVID-19 Ortigoza (DB RCT) -18% 1.18 [0.71-1.95] PASC 141 (n) 140 (n) PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) PennCCP2 Bar (RCT) 44% 0.56 [0.24-1.29] no improv. 40 (n) 39 (n) PennCCP2 Bar (RCT) 51% 0.49 [0.18-1.30] ventilation 5/40 10/39 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Sullivan (DB RCT) 25% 0.75 [0.17-3.32] ICU 3/592 4/589 Sullivan (DB RCT) 54% 0.46 [0.26-0.80] hosp. 17/592 37/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Jalili (RCT) -8% 1.08 [0.72-1.63] ICU 27/60 25/60 Jalili (RCT) -250% 3.50 [0.76-16.2] ARDS 7/60 2/60 Jalili (RCT) -10% 1.10 [0.89-1.36] hosp. time 60 (n) 60 (n) Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 PROTECT-Patient van den Berg (RCT) 67% 0.33 [0.04-3.04] ventilation 1/52 3/51 PROTECT-Patient van den Berg (RCT) 5% 0.95 [0.55-1.63] no improv. 16/47 18/50 PROTECT-Patient van den Berg (RCT) -3% 1.03 [0.62-1.71] no disch. 18/46 19/50 Mesina -29% 1.29 [0.70-2.36] death 18/65 14/65 Mesina -60% 1.60 [0.96-2.65] hosp. time 65 (n) 65 (n) De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 De Santis (RCT) 12% 0.88 [0.42-1.82] death 8/36 18/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 COPLA-II Bajpai (RCT) -19% 1.19 [0.69-2.06] death 25/200 21/200 COPLA-II Bajpai (RCT) -12% 1.12 [0.67-1.88] ventilation 27/200 24/200 COPLA-II Bajpai (RCT) -2% 1.02 [0.90-1.15] ICU 200 (n) 200 (n) COPLA-II Bajpai (RCT) 0% 1.00 [0.91-1.09] hosp. time 200 (n) 200 (n) COPLA-II Bajpai (RCT) 6% 0.94 [0.71-1.24] no recov. 64/200 68/200 COPLA-II Bajpai (RCT) -1% 1.01 [0.98-1.05] viral+ 200 (n) 200 (n) Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) Rojas (SB RCT) 38% 0.62 [0.40-0.97] no disch. 46 (n) 45 (n) Rojas (SB RCT) -25% 1.25 [0.36-4.33] viral+ 46 (n) 45 (n) Rojas (SB RCT) -16% 1.16 [0.33-4.08] viral+ 46 (n) 45 (n) Rojas (SB RCT) -51% 1.51 [0.33-6.98] viral+ 46 (n) 45 (n) Rojas (SB RCT) -12% 1.12 [0.16-7.84] viral+ 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] death 7/60 12/60 CORIPLASM Lacombe (RCT) 64% 0.36 [0.14-0.97] death 4/22 11/27 CORIPLASM Lacombe (RCT) -68% 1.68 [0.74-3.35] progression 13/60 8/60 CORIPLASM Lacombe (RCT) -4% 1.04 [0.61-1.78] progression 19/60 20/60 CORIPLASM Lacombe (RCT) -7% 1.07 [0.00-9700] hosp. time 60 (n) 60 (n) CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 CCAP-2 Thorlaci.. (DB RCT) -88% 1.88 [0.56-6.33] death 12/98 3/46 CCAP-2 Thorlaci.. (DB RCT) -72% 1.72 [0.50-5.87] death 11/98 3/46 CCAP-2 Thorlaci.. (DB RCT) -64% 1.64 [0.36-7.60] death 7/98 2/46 CCAP-2 Thorlaci.. (DB RCT) -735% 8.35 [0.47-148] death 5/98 0/46 CCAP-2 Thorlaci.. (DB RCT) -37% 1.37 [0.29-6.52] ventilation 6/94 2/43 CCAP-2 Thorlaci.. (DB RCT) -31% 1.31 [0.45-3.82] ICU 12/89 4/39 CCAP-2 Thorlaci.. (DB RCT) -41% 1.41 [0.72-2.09] 7-point status 98 (n) 46 (n) PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PLACO COVID Manzini (DB RCT) -10% 1.10 [0.61-1.95] death/int. 17/59 14/56 PLACO COVID Manzini (DB RCT) -6% 1.06 [0.70-1.61] viral time 60 (n) 60 (n) PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 PassItOn Self (DB RCT) -26% 1.26 [0.81-1.90] death 63/482 48/465 PassItOn Self (DB RCT) -4% 1.04 [0.82-1.33] 7-point status 487 (n) 473 (n) REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) Denkinger (RCT) -2% 1.02 [0.59-1.77] ventilation 19/68 18/66 Denkinger (RCT) 22% 0.78 [0.52-1.16] 7-point status 68 (n) 66 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 CSSC-004 Baksh (DB RCT) -4% 1.04 [0.79-1.39] PASC 533 (n) 528 (n) CSSC-004 Baksh (DB RCT) 9% 0.91 [0.60-1.37] PASC 232 (n) 234 (n) CSSC-004 Baksh (DB RCT) -18% 1.18 [0.80-1.74] PASC 301 (n) 294 (n) Alshamrani (PSM) -14% 1.14 [0.79-1.45] death 24/41 108/205 Alshamrani (PSM) -17% 1.17 [0.93-1.28] progression 34/41 154/205 Alshamrani (PSM) -43% 1.43 [1.13-1.80] ICU 37 (n) 166 (n) Alshamrani (PSM) -32% 1.32 [1.07-1.63] hosp. time 41 (n) 205 (n) Krishnan -270% 3.70 [0.90-15.8] death case control Kasten -4% 1.04 [0.49-2.21] death 7/19 11/31 Kasten -17% 1.17 [0.43-3.15] death 5/19 7/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 Co-CLARITY Gauiran (RCT) -100% 2.00 [0.20-20.5] ICU 2/22 1/22 Co-CLARITY Gauiran (RCT) -7% 1.07 [0.77-1.50] hosp. time 22 (n) 22 (n) Lewandowski -62% 1.62 [0.88-2.98] death 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 CP_COVID-19 Khawaja (DB RCT) 73% 0.27 [0.03-2.80] ventilation 1/37 2/20 CP_COVID-19 Khawaja (DB RCT) 46% 0.54 [0.12-2.43] ICU 3/37 3/20 Convalescent plasma COVID-19 outcomes c19early.org October 2024 ​1​ OT: comparison with other treatment Favors conv. plasma Favors control
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.
Submit    
Post
Share
@CovidAnalysis
FAQ
Public domain CC0 1.0